نتایج جستجو برای: chromomycin a3

تعداد نتایج: 7508  

Journal: :Applied and environmental microbiology 2006
Nuria Menéndez Mohammad Nur-e-Alam Carsten Fischer Alfredo F Braña José A Salas Jürgen Rohr Carmen Méndez

Chromomycin A3 is an antitumor drug produced by Streptomyces griseus subsp. griseus. It consists of a tricyclic aglycone with two aliphatic side chains and two O-glycosidically linked saccharide chains, a disaccharide of 4-O-acetyl-D-oliose (sugar A) and 4-O-methyl-D-oliose (sugar B), and a trisaccharide of D-olivose (sugar C), D-olivose (sugar D), and 4-O-acetyl-L-chromose B (sugar E). The chr...

2014
Larissa Alves Guimarães Paula Christine Jimenez Thiciana da Silva Sousa Hozana Patrícia S. Freitas Danilo Damasceno Rocha Diego Veras Wilke Jesús Martín Fernando Reyes Otília Deusdênia Loiola Pessoa Letícia Veras Costa-Lotufo

The present study highlights the biological effects of chromomycin A2 toward metastatic melanoma cells in culture. Besides chromomycin A2, chromomycin A3 and demethylchromomycin A2 were also identified from the extract derived from Streptomyces sp., recovered from Paracuru Beach, located in the northeast region of Brazil. The cytotoxic activity of chromomycin A2 was evaluated across a panel of ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1982
R G Langlois L C Yu J W Gray A V Carrano

Dual beam flow cytometry of chromosomes stained with Hoechst 33258 and chromomycin A3 has been proposed as a method for quantitative classification of human chromosomes (bivariate flow karyotyping). In this paper we investigate the sources and magnitudes of variability in the mean fluorescence intensities of each chromosome group resolved in bivariate flow karyotypes and study the impact of thi...

Journal: :research in molecular medicine 0
durdi qujeq babol univrsity of medical sciences

background: current microscopic experimental methods cannot diagnose dna damages present in spermatozoa .therefore, some methods are needed to address the abnormality of the genetic material status on the sperm samples. as reported by many investigators aniline blue staining technique has been used for identifying sperm chromatin condensation. also, chromomycin a3 is used for evaluation of the ...

Journal: :Applied and environmental microbiology 1998
S Y Liu J P Rosazza

All of the 2,6-dideoxy sugars contained within the structure of chromomycin A3 are derived from D-glucose. Enzyme assays were used to confirm the presence of hexokinase, phosphoglucomutase, UDPG pyrophosphorylase (UDPGP), and UDPG oxidoreductase (UDPGO), all of which are involved in the pathway of glucose activation and conversion into 2,6-dideoxyhexoses during chromomycin biosynthesis. Levels ...

2011
Beatriz García Javier González‐Sabín Nuria Menéndez Alfredo F. Braña Luz Elena Núñez Francisco Morís José A. Salas Carmen Méndez

Mithramycin and chromomycin A(3) are two structurally related antitumour compounds, which differ in the glycosylation profiles and functional group substitutions of the sugars. Chromomycin contains two acetyl groups, which are incorporated during the biosynthesis by the acetyltransferase CmmA in Streptomyces griseus ssp. griseus. A bioconversion strategy using an engineered S. griseus strain ge...

Journal: :Applied microbiology 1971
R F Pittillo C Woolley

A microbiological assay has been developed for chromomycin A(3), an antitumor antibiotic showing promise in human trials. The assay bacterium is a derived strain of Streptococcus faecalis resistant to methotrexate. Studies with mice revealed that relatively high concentrations of this antibiotic were maintained in the blood, kidneys, and liver of mice after a single-dose intraperitoneal injecti...

Marzeyeh Tavalaee Mohammad Hossein Nasr Esfahani, shahnaz Razavi

Chromomycin A3 binds to DNA and Protamine -deficient spermatozoa look bright yellow,whereas normal spermatozoa appear dull yellow.

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